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List of Treatments for Chronic Hives

See what members are saying about chronic hives treatments, the side effects to expect, and the drug basics.

All treatment information is medically reviewed · December 10, 2025

Cetirizine

Overview
Cetirizine is approved by the U.S. Food and Drug Administration (FDA) to chronic hives. It is used to relieve persistent itching, swelling, and discolored, raised skin welts. 

Cetirizine is a second-generation…

Desloratadine

Overview
Desloratadine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic idiopathic urticaria (hives). It is used to relieve symptoms such as pruritus (itching), and to reduce the…

Dupixent (Dupilumab)

Overview
Dupixent is approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic spontaneous urticaria (CSU) in adults and adolescents aged 12 years and older who continue to have symptoms despite…

Fexofenadine

Overview
Fexofenadine is approved by the U.S. Food and Drug Administration (FDA) to treat chronic idiopathic urticaria, also known as chronic hives. It is used to relieve symptoms such as discolored, raised, itchy areas…

Hydroxyzine

Overview
Hydroxyzine is approved by the U.S. Food and Drug Administration (FDA) for the management of pruritus (itching) caused by allergic conditions such as chronic urticaria (hives). It is available in both tablet and…

Levocetirizine

Overview
Levocetirizine is approved by the U.S. Food and Drug Administration (FDA) to treat chronic idiopathic urticaria, a condition also known as chronic hives. It is used to relieve symptoms such as persistent itching…

Loratadine

Overview
Loratadine is approved by the U.S. Food and Drug Administration (FDA) for the relief of symptoms associated with chronic idiopathic urticaria (hives). It is used to temporarily reduce pruritus (itching), the…

Rhapsido (Remibrutinib)

Overview
Rhapsido is approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic spontaneous urticaria (CSU), a type of hives, in adults who continue to experience symptoms despite taking H1…

Xolair (Omalizumab)

Overview
Xolair is approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic spontaneous urticaria (CSU) in adults and adolescents aged 12 years and older who continue to have hives despite…

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