Living with chronic hives (also called chronic urticaria) can make every day feel like an uphill battle against itching and discomfort. Scratching often makes symptoms worse. One over-the-counter (OTC) remedy some people consider is calamine lotion. Although calamine lotion doesn’t cure chronic hives, some people find that it can offer gentle, short-term relief from itching and irritation.

In this article, we’ll cover what calamine lotion is, how it may help with chronic hives, and how to use it safely. As always, talk with your healthcare provider before trying calamine lotion or any new home remedy for chronic hives.

What Is Calamine Lotion?

Calamine lotion is an OTC anti-itch medication. It’s used to relieve itching and skin irritation caused by insect bites, poison ivy, sunburn, viral infections such as shingles and chickenpox, and other mild skin conditions. It’s a topical treatment, meaning it’s applied directly to the skin. Side effects are rare.

The two main ingredients in calamine lotion are zinc oxide and iron oxide. The iron oxide gives the lotion its signature pink color. Other ingredients include water, glycerin, calcium hydroxide, and bentonite magma.

As it dries, calamine lotion creates a gentle cooling and drying effect on the skin. This helps soothe itching and irritation. It may reduce mild inflammation, absorb excess moisture, and form a protective barrier over the affected area. The zinc oxide also has antiseptic (infection-preventing), anti-inflammatory, and astringent (skin-tightening) properties. This may help calm inflamed skin and promote healing.

Calamine lotion isn’t a cure for any skin condition. But it can offer temporary relief from itchy skin and irritation, including, in some cases, flare-ups caused by chronic hives.

Chronic Hives and Calamine Lotion

Depending on the type and severity of your chronic hives, calamine lotion may offer varying levels of relief.

Two Types of Chronic Hives

Chronic hives are hives that last for six weeks or longer. There are two types of chronic hives.

When you can’t identify the underlying cause of hives, it’s called chronic spontaneous urticaria (CSU), also known as chronic idiopathic urticaria (CIU). Researchers believe this type of chronic hives may sometimes be linked to an autoimmune disease. This means the body’s immune system mistakenly triggers the release of histamine.

For CSU or CIU, antihistamines are typically the first-line treatment doctors recommend. They help block histamine and reduce itching and swelling. In more persistent cases, biologic medications such as omalizumab (Xolair) can help calm the immune system and prevent new flare-ups.

Sometimes, chronic hives are triggered by specific physical or environmental factors. These may include temperature changes, sunlight, skin friction, physical activity, or exposure to cold water. In those cases, the condition is called chronic inducible urticaria (CIndU). With CIndU, avoiding or minimizing exposure to common triggers may help. But many people require additional treatment options or a combination of therapies to manage their symptoms.

A Comprehensive Treatment Plan

Calamine lotion is best used as part of a wider treatment plan developed with your healthcare provider. Dermatologists sometimes include calamine lotion among home remedies for soothing chronic hives. They may also suggest oatmeal baths, aloe vera gel, and cool compresses. Calamine lotion won’t prevent new welts from forming. But it can help relieve itching and irritation on the skin’s surface.

Managing chronic hives often requires ongoing care to identify triggers, adjust medications, and control symptoms. If calamine lotion provides relief for you, it may be a safe, affordable, and effective addition to your chronic hives care routine.

How To Use Calamine Lotion

Calamine lotion is safe for most people, but it should only be used on the skin. It can be harmful if swallowed or if it comes into contact with sensitive areas. Avoid using it near your eyes, the inside of your nose or mouth, or the genital and anal regions. Always follow the directions on the product label or any guidance provided by your dermatologist, allergist, or other healthcare provider.

Here are some general steps for safe application:

1. Clean the affected area with mild soap and water, then gently pat it dry.
2. Shake the bottle well to mix the ingredients evenly.
3. Pour a small amount of lotion onto a clean cotton ball, gauze, or washcloth and gently dab it onto your skin.
4. Allow the lotion to dry completely.
5. Wash your hands thoroughly.

You can also use your fingers to apply calamine lotion. But be sure to wash your hands with soap and water before and after application. Calamine lotion may stain clothing or other fabrics, so it’s best to wait until it dries completely before getting dressed or sitting on furniture.

When To Seek Medical Attention

Severe allergic reactions to calamine lotion are rare. But you should seek immediate medical attention if you experience symptoms of an allergic reaction, such as:

• Difficulty breathing or swallowing
• Dizziness or fainting
• Rash spreading beyond the treated area
• Swelling of the face, lips, tongue, or throat
• Tightness in the chest
• Fever

If you accidentally swallow calamine lotion, call a poison control center or your local emergency services right away.

When To Consult Your Healthcare Provider

Calamine lotion can provide short-term relief from mild itching or irritation. But it isn’t a long-term treatment for chronic hives.

If you experience persistent hives, or if your symptoms interfere with your sleep or daily activities, talk to a doctor. They can help identify possible triggers and create an effective, long-term treatment plan. This may include oral antihistamines, corticosteroids, prescription medications, or lifestyle changes to reduce exposure to common triggers.

Working together, you and your healthcare team can help keep your skin calm and your symptoms under control.

Join the Conversation

On MyChronicHivesTeam, people share their experiences with hives, get advice, and find support from others who understand.

Have you tried calamine lotion for chronic hives? Let others know in the comments below.