Overview
Cyproheptadine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of cold urticaria, a type of allergic skin reaction triggered by exposure to cold temperatures. People diagnosed with cold urticaria may be prescribed cyproheptadine to reduce symptoms such as itching, swelling, and hives. 

Cyproheptadine is an antihistamine and antiserotonergic medication. It is believed to help treat cold urticaria by blocking the action of histamine and serotonin, two natural substances in the body that are involved in allergic reactions and skin inflammation.

How do I take it?
Prescribing information states that cyproheptadine is available in tablet and syrup forms for oral use. Doses are typically taken two to three times a day, depending on age, weight, and response to treatment. Cyproheptadine should be taken exactly as directed by a healthcare provider.

Side effects
Common side effects of cyproheptadine include drowsiness, dizziness, dry mouth, confusion, nausea, increased appetite, and weight gain.

Rare but serious side effects may include hallucinations, seizures, hypotension (low blood pressure), urinary retention, blurred vision, liver problems such as jaundice (yellowing of the skin or eyes), and severe allergic reactions such as rash or swelling.

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Label: Cyproheptadine Hydrochloride Tablet — DailyMed

Label: Cyproheptadine — Cyproheptadine Hydrochloride Syrup — DailyMed